109 Results for "

Garcinia oblongifolia Champ. ex Benth.

" in MedChemExpress (MCE) Product Catalog:
Products (109)

109 Results for "Garcinia oblongifolia Champ. ex Benth." in MCE Product Catalog:

8
Dihydrokaempferol
Dihydrokaempferol
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8 Publications Verification
Cat. No.: HY-N2897
CAS No.: 480-20-6
Category:  

Flavanonols Flavonoids Leguminosae Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Bcl-2 Family

Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .
7
Tectorigenin
Tectorigenin
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7 Cited Publications
Cat. No.: HY-N0792
CAS No.: 548-77-6
Category:  

Flavonoids Leguminosae Pueraria lobate (Willd.) Ohwi Plants Disease Research Fields Inflammation/Immunology Cancer Isoflavones

Target:  

Others

Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria lobate Benth.
6
Gambogic Acid
Gambogic Acid
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6 Cited Publications
Cat. No.: HY-N0087
CAS No.: 2752-65-0
Synonyms: Beta-Guttiferrin
Category:  

Natural Products Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer

Target:  

Bcl-2 Family Autophagy

Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.
5
Garcinol
Garcinol
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5 Cited Publications
Cat. No.: HY-107569
CAS No.: 78824-30-3
Purity:  ≥99.0%
Category:  

Guttiferae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Garcinia indica

Target:  

Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .
2
Garcinone C
Garcinone C
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2 Cited Publications
Cat. No.: HY-N6954
CAS No.: 76996-27-5
Category:  

other families Xanthones Garcinia oblongifolia Champ. ex Benth. Guttiferae Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

ATM/ATR STAT CDK Hedgehog

Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active .
1
Morellic acid
Morellic acid
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1 Cited Publications
Cat. No.: HY-N4094
CAS No.: 5304-71-2
Category:  

Natural Products other families Monophenols Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Others

Morellic acid is isolated from Garcinia Morella with an antiangiogenic activity .
1
Hydroxycitric acid tripotassium
Hydroxycitric acid tripotassium
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1 Cited Publications
Cat. No.: HY-W338584
CAS No.: 232281-44-6
Tripotassium hydroxycitrate is an orally active, multi-target, multi-bioactive organic acid. Tripotassium hydroxycitrate activates Nrf2 and its downstream molecule GPX4, increases glutathione levels, and thereby inhibits ferroptosis. Tripotassium hydroxycitrate activates the Nrf2/Keap1 and ACLY/NF-κB signaling pathways, upregulates the activities of antioxidant enzymes such as superoxide dismutase, reduces MDA content, thereby alleviating oxidative stress and renal tubular epithelial cell apoptosis, and improves pulmonary vascular and right ventricular remodeling. Tripotassium hydroxycitrate activates both the AMPK and mTORC1/S6K pathways, triggers the unfolded protein response, arrests the cancer cell cycle, and induces DNA fragmentation .
Macurin
Macurin
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Cat. No.: HY-N3347
CAS No.: 519-34-6
Synonyms: Maclurin
Category:  

Garcinia lancilimba C. Y. Wu ex Y. H. Li Guttiferae Phenols Polyphenols Plants

Target:  

Others

Macurin is a xanthone that can be isolated from Garcinia lancilimba .
(-)-Hydroxycitric acid lactone
(-)-Hydroxycitric acid lactone
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Cat. No.: HY-N7347
CAS No.: 27750-13-6
Synonyms: Garcinia lactone
Category:  

other families Ketones, Aldehydes, Acids Metabolic Disease Plants Disease Research Fields

Target:  

ATP Citrate Lyase

(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .
Androsin
Androsin
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Cat. No.: HY-N1399
CAS No.: 531-28-2
Category:  

Ketones, Aldehydes, Acids Scrophulariaceae Plants Picrorhiza scrophulariiflora Pennell Disease Research Fields Inflammation/Immunology

Target:  

AMPK PI3K Autophagy

Androsin is an active compound isolated from Picrorhiza Kurroa Royle ex Benth. Androsin activates AMPKα/PI3K/Beclin1/LC3 signaling pathway, inhibits SREBP1c/FASN signaling pathway. Androsin can be used in research of asthma and non-alcoholic fatty liver disease (NAFLD). Androsin is orally active .
Garcinia cambogia extract
Garcinia cambogia extract
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Cat. No.: HY-N14035
CAS No.: 90045-23-1
Category:  

Natural Products Guttiferae Garcinia cambogia Desr. Plants

Target:  

FABP PPAR

Garcinia cambogia extract is an orally active anti-obesity agent . Garcinia cambogia extract upregulates the gene expression of aP2, SREBP1c, PPARγ2 and C/EBPα. Garcinia cambogia extract reduces the rate of body weight gain, visceral fat accumulation, lipid levels in blood and liver, as well as plasma insulin and leptin levels . Garcinia cambogia extract ameliorates high-fat diet-induced obesity .
Humantenine
Humantenine
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Cat. No.: HY-N4031
CAS No.: 82375-29-9
Category:  

Alkaloids Other Diseases Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Disease Research Fields Indole Alkaloids

Target:  

Anaplastic lymphoma kinase (ALK) METTL3

Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD50 values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes .
Buddlejasaponin IVb
Buddlejasaponin IVb
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Cat. No.: HY-N2138
CAS No.: 152580-79-5
Category:  

Triterpenes Prosopis juliflora (Sw.) DC. Labiatae Dipsacaceae Terpenoids Dipsacus asper Wall. Plants Disease Research Fields Inflammation/Immunology

Target:  

Others

Buddlejasaponin IVb (Compound 2), a triterpene saponin isolated from Clinopodium chinense (Benth.) O. Kuntze, Compound 2 has hemostasis efficacy, shortens thrombin time (TT) by 20.6 % .
9-Hydroxycalabaxanthone
9-Hydroxycalabaxanthone
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Cat. No.: HY-N2795
CAS No.: 35349-68-9
Synonyms: Xanthone I
Target:  

Parasite Bacterial

Research Areas:  

Infection

9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 μM) .
Frangulin A
Frangulin A
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Cat. No.: HY-N8344
CAS No.: 521-62-0
Category:  

Ventilago leiocarpa Benth. Quinones Anthraquinones Plants Rhamnaceae

Target:  

Others

Frangulin A is a emodin derivative. Frangulin A can be obtained from Ventilago leiocarpa Benth .
Neosmitilbin
Neosmitilbin
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Cat. No.: HY-N5115
CAS No.: 54081-47-9
Category:  

Flavanonols other families Flavonoids Other Diseases Phenols Polyphenols Plants Disease Research Fields

Target:  

Others

Neosmitilbin is isolated from Garcinia mangostana.
Thaumatins
Thaumatins
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Cat. No.: HY-W540600
CAS No.: 53850-34-3
Category:  

Marantaceae Thaumatococcus daniellii (Benn.) Benth. Natural Products Other Diseases Plants Disease Research Fields Sweeteners Food Research

Target:  

Environmental Pollutants

Thaumatins is a protein, which can be purified from the fruit of Thaumatococcus daniellii Benth. Thaumatins is 100,000 times sweeter than sucrose on a molar basis .
Cowaxanthone B
Cowaxanthone B
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Cat. No.: HY-N6248
CAS No.: 212842-64-3
Category:  

Infection other families Xanthones Phenols Polyphenols Plants Disease Research Fields

Target:  

Bacterial

Cowaxanthone B is a xanthone isolated from the fruits of Garcinia cowa. Cowaxanthone B has weak antibacterial activity .
Millepachine
Millepachine
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Cat. No.: HY-N7591
CAS No.: 1393922-01-4
Category:  

Flavonoids Chalcones Leguminosae Millettia pachycarpa Benth. Plants Disease Research Fields Cancer

Target:  

Apoptosis

Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .
1,3,5,6-Tetrahydroxyxanthone
1,3,5,6-Tetrahydroxyxanthone
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Cat. No.: HY-N9113
CAS No.: 5084-31-1
Category:  

Flavonoids Guttiferae Hyperlcurn perforatum L. Plants Other Flavonoids

Target:  

Others

1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .
Assay Types